| Document ID (ISN) | 40188 |
| CIS number |
83-1321 |
| Year |
1983 |
| Convention or series no. |
ECETOC JACC No.2
|
| Title |
Joint assessment of commodity chemicals - No.2: 1,4-Dioxane |
| Bibliographic information |
European Chemical Industry, Avenue Louise 250, 1050 Bruxelles, Belgium, Feb. 1983, 13p. 31 ref. |
| Abstract |
Concentrations of 1,4-dioxane (1,4-D) of ≥300ppm cause eye, nose and throat irritation in humans, and acute over-exposure can cause death. The acute toxicity to animals is low. 1,4-D is not mutagenic, and there is evidence that it has no effects on reproduction in mice. The carcinogenic risk for humans is not clear and future epidemiologic studies are recommended. Contents: chemical identity, physical and chemical properties; production and uses; human exposure; toxicological data (human; acute, subchronic and chronic toxicity, carcinogenicity; metabolism and pharmacokinetics; mutagenicity); ecotoxicological data; summary and conclusions; bibliography. |
| Descriptors (primary) |
dioxane; chemical products; toxicology |
| Descriptors (secondary) |
mutagenic effects; acute toxicity; metabolic process; data sheet; chronic toxicity; carcinogenic effects; animal experiments |
| Document type |
B - Chemical safety information sheets |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Genetic factors in reaction to exposures
Ethers
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