| Document ID (ISN) | 40060 |
| CIS number |
83-1027 |
| ISSN - Serial title |
Cahiers de notes documentaires - Sécurité et hygiène du travail |
| Year |
1983 |
| Convention or series no. |
|
| Title |
Toxicity to man of ethylene glycol monoalkyl ethers |
| Original title |
Toxicité pour l'homme des éthers monoalkylés de l'éthylèneglycol [in French] |
| Bibliographic information |
2nd quarter 1983, No.111, Note No.1422-111-83, p.215-230. Illus. 58 ref. |
| Abstract |
This note, based on Technical Report No.4 of the European Chemical Industry Ecology and Toxicology Centre (Brussels, July 1982), reviews the existing data on the toxicity of glycol ethers, mainly monomethyl and monoethyl ethylene glycol. Animal experiments show that these 2 products have adverse haematological and testicular effects, and are teratogenic and foetotoxic. These properties are more pronounced in the case of the methyl ether. Monoisopropyl ether and monobutyl ethylene glycol have predominantly haemolytic effects, the testicular effects being weak or absent. Haematological and neurological effects similar to those occurring in animals have been observed in humans heavily exposed to ethylene glycol monomethyl ether. Conclusion: further study is necessary as a basis for revising the limits of occupational exposure presently in force. |
| Descriptors (primary) |
toxicology; glycol ethers |
| Descriptors (secondary) |
embryotoxic effects; haematotoxic effects; ethoxyethanol; 2-phenoxyethanol; threshold limit values; butoxyethanol; 1-methoxy-2-propanol; diseases of genital organs; methoxyethanol; propoxyethanol; 2-ethoxyethyl acetate; 2-methoxyethyl acetate; ethylene glycol monoacetate; ethylene glycol; animal experiments; human experiments; teratogenic effects; neurotoxic effects |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Genetic factors in reaction to exposures
Glycol ethers
|
