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CISDOC database

Document ID (ISN)39949
CIS number 83-1091
ISSN - Serial title Journal of the National Cancer Institute
Year 1983
Convention or series no.
Author(s) Rom W.N., Livingston G.K., Casey K.R., Wood S.D., Egger M.J., Chiu Gh., Jerominski L.
Title Sister chromatid exchange frequency in asbestos workers
Bibliographic information Jan. 1983, Vol.70, No.1, p.45-48. 28 ref.
Abstract A comparative study of 25 asbestos insulators (6 with radiographic asbestosis) and 14 age-matched controls showed the insulators to have a marginally increased sister chromatid exchange (SCE) rate in circulating lymphocytes with increasing years of exposure. There was a significant association between SCE rate and smoking after controlling for years of asbestos exposure and age. Smoking asbestos workers had the highest SCE rate. SCE in group A chromosomes, i.e. the group with the longest chromosomes, were significantly associated with asbestos exposure and cigarette smoking, with an interaction being apparent between the 2 factors.
Descriptors (primary) asbestos; chromosome changes; respirable dust
Descriptors (secondary) smoking; comparative study; synergism
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Asbestos
Genetic factors in reaction to exposures