| Document ID (ISN) | 39949 |
| CIS number |
83-1091 |
| ISSN - Serial title |
Journal of the National Cancer Institute |
| Year |
1983 |
| Convention or series no. |
|
| Author(s) |
Rom W.N., Livingston G.K., Casey K.R., Wood S.D., Egger M.J., Chiu Gh., Jerominski L. |
| Title |
Sister chromatid exchange frequency in asbestos workers |
| Bibliographic information |
Jan. 1983, Vol.70, No.1, p.45-48. 28 ref. |
| Abstract |
A comparative study of 25 asbestos insulators (6 with radiographic asbestosis) and 14 age-matched controls showed the insulators to have a marginally increased sister chromatid exchange (SCE) rate in circulating lymphocytes with increasing years of exposure. There was a significant association between SCE rate and smoking after controlling for years of asbestos exposure and age. Smoking asbestos workers had the highest SCE rate. SCE in group A chromosomes, i.e. the group with the longest chromosomes, were significantly associated with asbestos exposure and cigarette smoking, with an interaction being apparent between the 2 factors. |
| Descriptors (primary) |
asbestos; chromosome changes; respirable dust |
| Descriptors (secondary) |
smoking; comparative study; synergism |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Asbestos
Genetic factors in reaction to exposures
Antifertility and prenatal effects
|
