ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)39910
CIS number 83-1004
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1982
Convention or series no.
Author(s) Parodi S., Santi L., Russo P., Albini A., Vecchio D., Pala M., Ottaggio L., Carbone A.
Title DNA damage induced by auramine O in liver, kidney, and bone marrow of rats and mice, and in a human cell line (alkaline elution assay and SCE induction)
Bibliographic information May-June 1982, Vol.9, No.5-6, p.941-952. Illus. 31 ref.
Abstract DNA fragmentation in liver, kidney and bone marrow cells using commercial auramine O and the induction of sister chromatid exchanges in bone marrow cells are described. An intraperitoneal LD50 of 135mg/kg was determined.
Descriptors (primary) carcinogens; auramine O; chromosome changes; genetic effects; DNA
Descriptors (secondary) hepatotoxic effects; animal experiments; nephrotoxic effects; cell culture; myelotoxic effects
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Aromatic amines
Genetic factors in reaction to exposures