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Document ID (ISN)39838
CIS number 83-1057
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1982
Convention or series no.
Author(s) Sorenson W.G., Green F.H.Y., Vallyathan V., Ciegler A.
Title Secalonic acid D toxicity in rat lung
Bibliographic information Mar. 1982, Vol. 9, No.3, p.515-525. Illus. 13 ref.
Abstract Responses in these studies differed markedly according to the route of administration (intragastric or intratracheal). There were histological lesions in the lungs only when secalonic acid D was administered intratracheally: 24h after treatment, the lungs showed an acute polymorphonuclear reaction in the distal airways and adjacent alveoli with necrosis with airways epithelium, developing into typical bronchiolitic lesions. Granulomas appeared on day 3. All of the pulmonary damage was reversible on termination of therapy after 69 days.
Descriptors (primary) secalonic acid d; pneumotoxic effects; fungicides; toxicology
Descriptors (secondary) animal experiments; pulmonary granulomatosis
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Agricultural chemicals