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Document ID (ISN)39505
CIS number 83-733
ISSN - Serial title 0032-6291 - Pracovní lékařství
Year 1982
Convention or series no.
Author(s) Cikrt M., Tichý P., Kobrle V., Havrdová J., Hurych J., Škoda V.
Title Cadmiun and zinc concentration in the liver, kidneys and lungs and changes in pulmonary collagenous proteins following repeated inhalation of CdCl2 aerosols by rats
Original title Obsah kadmia a zinku v játrech, ledvinách, plících a změny plicních vazivových bílkovin po opakované inhalační expozici krys aerosolu CdCl2 [in Czech]
Bibliographic information Oct. 1982, Vol.34, No.9, p.299-304. Illus. 12 ref.
Abstract Male rats were exposed once a day for 5 days a week to CdCl2 aerosol at a concentration of 60mg/m3. Cadmium and zinc concentrations in the liver, kidneys and lungs and changes in the levels of pulmonary fibrous proteins were determined in relation to length of exposure (5, 10 and 20 days). There was a significant absorption of Cd into the lungs and progressive deposition of this metal in the kidneys and the liver in relation to the length of exposure. A high Zn concentration was found in the kidneys and liver of exposed animals. Cd exposure leads to an increase in the pulmonary level of collagen and elastin and a concomitant increase in total mass. Only the elastin concentration increases after 20 days Cd exposure.
Descriptors (primary) cadmium and compounds; zinc; body retention; connective tissue development; respirable dust
Descriptors (secondary) lung; liver; metabolic process; collagenous pneumoconiosis; kidney; dose-response relationship; cadmium chloride; cadmium; animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Cadmium and compounds
Inorganic substances