|Document ID (ISN)||39269|
|ISSN - Serial title
||0016-9900 - Gigiena i sanitarija
|Convention or series no.
||Gonadotoxic and embryotoxic effects of halothane
||O gonadotoksičeskom i ėmbriotoksičeskom dejstvii ftorotana [in Russian]|
||Apr. 1981, No.4, p.21-24. 17 ref.
||Results of animal experiments carried out with a view to investigating the effects of low concentrations of halothane (1,1,1-trifluoro-2-chloro-2-bromoethane), an inhalation anaesthetic, on the gonads, embryo and foetus. Halothane affects the gonads in both male and female rats, and the gonadotoxic effect is proportional to the concentration of the anaesthetic. Embryotoxic and teratogenic effects were observed neither in rats nor in mice. A threshold limit value of 20mg/m3 was established for halothane.
||embryotoxic effects; halothane; gonadotropic effects; toxicology; inhalation anaesthetics
||threshold limit values; genetic effects; animal experiments
||D - Periodical articles
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures