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Document ID (ISN)39269
CIS number 83-486
ISSN - Serial title 0016-9900 - Gigiena i sanitarija
Year 1981
Convention or series no.
Author(s) Anisimova I.G.
Title Gonadotoxic and embryotoxic effects of halothane
Original title O gonadotoksičeskom i ėmbriotoksičeskom dejstvii ftorotana [in Russian]
Bibliographic information Apr. 1981, No.4, p.21-24. 17 ref.
Abstract Results of animal experiments carried out with a view to investigating the effects of low concentrations of halothane (1,1,1-trifluoro-2-chloro-2-bromoethane), an inhalation anaesthetic, on the gonads, embryo and foetus. Halothane affects the gonads in both male and female rats, and the gonadotoxic effect is proportional to the concentration of the anaesthetic. Embryotoxic and teratogenic effects were observed neither in rats nor in mice. A threshold limit value of 20mg/m3 was established for halothane.
Descriptors (primary) embryotoxic effects; halothane; gonadotropic effects; toxicology; inhalation anaesthetics
Descriptors (secondary) threshold limit values; genetic effects; animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Halogenated hydrocarbons
Genetic factors in reaction to exposures