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CISDOC database

Document ID (ISN)38921
CIS number 83-154
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1982
Convention or series no.
Author(s) Guillemin M., GubÚran E.
Title Value of the simultaneous determination of P-CO2 in monitoring exposure to 1,1,1-trichloroethane by breath analysis
Bibliographic information May 1982, Vol.39, No.2, p.161-168. Illus. 19 ref.
Abstract The P-CO2 was measured as a correction factor in the monitoring of solvent exposure by breath analysis. Volunteers were exposed to 200ppm 1,1,1-trichloroethane for 8h, and alveolar samples were taken 15-19h later by voluntary hyperventilation, 10-s breath holding and the "standard" method for simultaneous P-CO2 and solvent determination. The results of breath analyses for solvent exposure should be corrected for hyperventilation or hypoventilation and for dilution of alveolar air with dead-space air by a proportional adjustment of the solvent concentration at the mean normal alveolar P-CO2 or by disregarding samples with a P-CO2 outside the normal range. Monitoring exposure by breath analysis would have little meaning without such an adjustment or rejection criterion.
Descriptors (primary) trichloroethane; carbon dioxide; determination in exhaled air; exposure tests; organic solvents
Descriptors (secondary) 1,1,1-trichloroethane; human experiments; pulmonary ventilation; accuracy
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Biological monitoring
Carbon dioxide
Halogenated hydrocarbons
Inorganic substances