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Document ID (ISN)38919
CIS number 83-152
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1982
Convention or series no.
Author(s) Karai I., Fukumoto K., Horiguchi S.
Title Mechanism of increased osmotic resistance of red cells in workers exposed to lead
Bibliographic information May 1982, Vol.39, No.2, p.153-156. Illus. 17 ref.
Abstract The mechanism of increased osmotic resistance in red blood cells in lead workers was studied by examining 19 lead refining workers and 18 controls for red cell count, haematocrit, mean corpuscular volume, blood and urine lead concentrations, urine coproporphyrin and delta-aminolaevulinic acid (DALA), osmotic resistance of red cells, lecithin-cholesterol acyltransferase (LCAT) activity in serum, and cholesterol content and cholesterol-to-phospholipid ratio of the red cell membrane. Osmotic resistance of red cells, red cell membrane cholesterol content, blood and urine lead, urine coproporphyrin and urine DALA were higher in lead workers than in controls. In lead workers, close correlations were found between osmotic resistance and blood lead concentration, osmotic resistance, LCAT activity and red cell membrane cholesterol.
Descriptors (primary) lead; erythrocytes; lead industry; fragility of blood cells
Descriptors (secondary) blood count; urinary ala monitoring; dose-response relationship; comparative study; urine monitoring; enzyme activity determination; blood cytology; blood monitoring
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Blood diseases
Smelting and refining operations
Lead and compounds
Inorganic substances