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CISDOC database

Document ID (ISN)38739
CIS number 82-1969
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1982
Convention or series no.
Author(s) Buffler P.A., Aase J.M.
Title Genetic risks and environmental surveillance: Epidemiological aspects of monitoring industrial populations for environmental mutagens
Bibliographic information Apr. 1982, Vol.24, No.4, p.305-314. 11 ref.
Abstract Criteria are proposed for a desirable system of surveillance for detecting deleterious genetic effects of occupational exposures, and existing and suggested surveillance systems for industrial populations are reviewed against these criteria (sentiel phenotypes, protein markers, changes in chromosome number and structure, sex ratio, birth defects, major malformations, minor malformations, spontaneous abortion and infertility). At present, monitoring for infertility and loss of reproductivity seems to be the technique best suited for surveillance of industrial populations. However, monitoring techniques based on these events do not directly assess mutagenicity. Nevertheless, since f┐tal death and infertility are strongly, but not exclusively, correlated with mutation, these methods may be considered as an early-warning system to indicate when and where more definitive studies are needed. French translation may be obtained from INRS, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France.
Descriptors (primary) mutagens; medical supervision; genetic effects
Descriptors (secondary) antifertility effects; translation; analysis of chromosome aberrations; cytogenetic studies
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects