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Document ID (ISN)38650
CIS number 82-1950
ISSN - Serial title 0003-0805 - American Review of Respiratory Disease
Year 1982
Convention or series no.
Author(s) Malo J.L., Zeiss C.R.
Title Occupational hypersensitivity pneumonitis after exposure to diphenylmethane diisocyanate
Bibliographic information Jan. 1982, Vol.125, No.1, p.113-116. Illus. 29 ref.
Abstract A foundry worker developed dyspnoea and a restrictive breathing defect after exposure to diphenylmethane diisocyanate (MDI). His symptoms and lung function impairment subsided after he left foundry work. Specific inhalation challenges with MDI induced general malaise, a significant increase in body temperature and leukocyte count, and a decrease in forced vital capacity and transfer factor. Total antibody activity to a MDI human serum albumin conjugate was detected by ammonium sulfate precipitation and specific IgG antibodies were demonstrated by the enzyme-linked immunoabsorbent technique.
Descriptors (primary) diphenylmethane diisocyanate; extrinsic allergic alveolitis; foundries; immunology; moulding and coremaking
Descriptors (secondary) case study; respiratory impairment; haematological changes; immunoglobulin changes
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Pneumoconioses
Isocyanates
Cyano compounds
Foundries, metalcasting and forging operations