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Document ID (ISN)38556
CIS number 82-1709
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1981
Convention or series no.
Author(s) Nordenson I., Sweins A., Beckman L.
Title Chromosome aberrations in cultured human lymphocytes exposed to trivalent and pentavalent arsenic
Bibliographic information Dec. 1981, Vol.7, No.4, p.277-281. 18 ref.
Abstract Cultured human lymphocytes from healthy individuals were exposed to sodium arsenic (trivalent) and sodium arsenate (pentavalent) at concentrations comparable to the arsenic (As) levels found in the urine of copper smelter workers. Significantly increased frequencies of chromosome aberrations were found after exposure to trivalent but not pentavalent As. This effect was not found when non-stimulated lymphocytes were exposed to trivalent As and then cultured. The rate of sister chromatid exchanges was also increased after exposure to trivalent As. Trivalent As is more genotoxic than pentavalent As and exerts its effect mainly during cell division.
Descriptors (primary) arsenic and compounds; chromosome changes; genetic effects
Descriptors (secondary) lymphocytes; sodium arsenate; smelting plants; copper ores; human experiments; sodium arsenite
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Arsenic and compounds
Inorganic substances
Genetic factors in reaction to exposures