| Document ID (ISN) | 38405 |
| CIS number |
82-1547 |
| ISSN - Serial title |
0098-4108 - Journal of Toxicology and Environmental Health |
| Year |
1982 |
| Convention or series no. |
|
| Author(s) |
Castranova V., Bowman L., Shreve J.M., Jones G.S., Miles P.R. |
| Title |
Volcanic ash: toxicity to isolated lung cells |
| Bibliographic information |
Feb. 1982, Vol.9, No.2, p.317-325. Illus. 24 ref. |
| Abstract |
The toxicity of ash from the Mount St. Helens eruption, of 18 May 1980, was estimated by monitoring the effects of in-vitro and in-vivo exposure on various physiological parameters of lung cells. The ash had little effect on oxygen consumption of rabbit type II pneumocytes, oxygen consumption or superoxide release of resting rat alveolar macrophages, or membrane integrity of rat alveolar macrophages. No significant lipid peroxidation in lung microsomes was found. The ash did inhibit superoxide anion release from zymosan-stimulated macrophages and may adversely affect the ability of these to protect the lung from infection. The findings are significant for workers exposed to ash during reclamation or logging of affected areas. |
| Descriptors (primary) |
toxic effects; volcanism; ashes; respirable dust; lung deposition |
| Descriptors (secondary) |
macrophages; blood-cell anomalies; immunology; exposure evaluation; biochemistry of the lung |
| Document type |
D - Periodical articles |
| Subject(s) |
Dust, aerosols and related diseases
|
| Broad subject area(s) |
|
| Browse category(ies) |
Natural phenomena
|
