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CISDOC database

Document ID (ISN)38404
CIS number 82-1665
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1982
Convention or series no.
Author(s) York R.G., Sowry B.M., Hastings L., Manson J.M.
Title Evaluation of teratogenicity and neurotoxicity with maternal inhalation exposure to methyl chloroform
Bibliographic information Feb. 1982, Vol.9, No.2, p.251-266. Illus. 19 ref.
Abstract In 4 groups of female rats, 1 was exposed to 2100▒200ppm methyl chloroform (MC) for 2 weeks before mating and through day 20 of gestation, a second group was exposed only before mating, a third only during pregnancy and a fourth was exposed to filtered air as a control. At term, half of each group were sacrified and assessed for maternal toxicity, embryotoxicity and teratogenicity. No significant differences were found in measurements of maternal toxicity or embryotoxicity except for a decrease in foetal body weight when rats were exposed during pregnancy alone. Increased incidences of skeletal and soft tissue variations were found in foetuses from the group exposed before mating and during pregnancy. In a post-natal evaluation of offspring from half the sample no significant effects of exposure were noted in body weight or neuro-behavioral tests of open-field activity.
Descriptors (primary) neurotoxic effects; trichloroethane; expectant mothers; teratogenic effects; toxicology
Descriptors (secondary) embryotoxic effects; 1,1,1-trichloroethane; inhalation toxicity; animal experiments; exposure evaluation
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Diseases of the nervous system
Halogenated hydrocarbons
Genetic factors in reaction to exposures
Antifertility and prenatal effects