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CISDOC database

Document ID (ISN)38322
CIS number 82-1646
ISSN - Serial title Staub
Year 1981
Convention or series no.
Author(s) Marshall M.
Title Effects of low carbon monoxide concentrations on the cardiovascular system
Original title Wirkungen niedriger Kohlenmonoxidkonzentrationen auf das Herzkreislaufsystem [in German]
Bibliographic information Aug. 1981, Vol.41, No.8, p.296-300. Illus. 34 ref.
Abstract The possible modification of the threshold limit value for carbon monoxide is discussed with a review of current knowledge as to the effects of low CO concentrations (equivalent to a maximum COHb level of 6%) on the cardiovascular system: mechanism of blood oxygen transport inhibition, incidence of CO in industry, animal experiments and human studies. COHb levels between 3 and 10% produce functional lesions; higher levels (9-15%) produce morphological lesions in the cardiovascular system. The threshold limit value for CO should be such that the COHb level remains 3% in order to eliminate all possible hazard. Review of relevant factors such as the method of determining CO and COHb levels, the objective of the threshold limit value, the type of exposure, the species of animal, and smoking.
Descriptors (primary) threshold limit values; blood circulation; carboxyhaemoglobin level; carbon monoxide
Descriptors (secondary) animal experiments; biological effects; human experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Blood diseases
Cardiovascular diseases
Carbon monoxide
Inorganic substances
Occupational exposure limits