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Document ID (ISN)38269
CIS number 82-1396
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1981
Convention or series no.
Author(s) Murray T., Walker B.R., Spratt D.M., Chappelka R.
Title Cadmium nephropathy: Monitoring for early evidence of renal dysfunction
Bibliographic information July-Aug. 1981, Vol.36, No.4, p.165-171. 25 ref.
Abstract In an attempt to establish a screening method for early detection of cadmium-induced nephropathy at a reversible stage, periodic analyses of cadmium (Cd) level were determined in the blood, urine, and hair of 23 workers exposed to platics and pigments containing a Cd stabiliser. Urine cytology, creatinine clearance and urinary levels of lysozyme, β-2-microglobulins, immunoglobulins and aminoacids were also monitored. Cd levels in blood and urine were only useful as indicators of acute environmental exposure. Hair Cd content was elevated in most workers. Urine cytology was not reliable as an indicator of possible nephropathy. All 5 measures of renal function are recommended in screening and follow-up of Cd workers.
Descriptors (primary) renal dysfunction; cadmium; exposure tests; nephrotoxic effects
Descriptors (secondary) amino acids; lysozymes; urinary electrolyte changes; immunoglobulin changes; pigments; creatinine excretion; blood monitoring; urine monitoring; urine cytology; determination in hair; plastics industry
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Diseases of the kidney and the urinary system
Cadmium and compounds
Inorganic substances
Biological monitoring