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Document ID (ISN)38079
CIS number 82-1357
ISSN - Serial title Cahiers de notes documentaires - Sécurité et hygiène du travail
Year 1982
Convention or series no.
Author(s) Siou G., Conan-Lerond L., Benoist G.
Title Screening for chromosomal aberrations in man - Some examples of its application to occupational exposure to chemicals
Original title Recherches des anomalies chromosomiques chez l'homme - Quelques exemples d'application à l'exposition aux produits chimiques [in French]
Bibliographic information 2nd quarter 1982, No.107, Note No.1379-107-82, p.269-276. Illus. 54 ref.
Abstract A method generally used for chromosomal analysis is presented, and the main morphological abnormalities that may appear spontaneously are summarised. In a survey of 109 persons not exposed to chemicals, abnormalities, mainly of the "gap" or "break" type, were present in 76.1% of the cases. A brief review of the literature, giving results of studies of workers exposed to benzene, vinyl chloride monomer, and some metals, showed that these substances induce increased chromosome changes. (English translation available from Canadian Centre for Occupational Health and Safety, 250 Main Street E., Hamilton, Ont. L8N 1H6, Canada. (CCOHS translation series No.141)).
Descriptors (primary) mutagens; chemical products; analysis of chromosome aberrations; chromosome changes; genetic effects
Descriptors (secondary) literature survey; vinyl chloride; description of technique; cytogenetic studies; translation; benzene
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects