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Document ID (ISN)38070
CIS number 82-1354
ISSN - Serial title 0003-0805 - American Review of Respiratory Disease
Year 1981
Convention or series no.
Author(s) Chichester C.O., Palmer K.C., Hayes J.A., Kagan H.M.
Title Lung lysyl oxidase and prolyl hydroxylase: Increases induced by cadmium chloride inhalation and the effect of β-aminopropionitrile in rats
Bibliographic information Dec. 1981, Vol.124, No.6, p.709-713. Illus. 30 ref.
Abstract Rats were exposed for 2h to 0.1% cadmium chloride aerosol and were killed 2, 4, 7, 10 and 21 days after exposure. At 4 days lung lysyl oxidase (LO) was increased 14.8 times compared with control animals and returned to near normal at 10 days. Total lung prolyl hydroxylase (PH) activity increased 7.4 times by day 4 in exposed versus unexposed animals. A significant increase in total lung hydroxyproline was also observed. Administration of β-aminopropionitrile prevented much of the increase in LO activity and the accumulation of collagen. The altered tissue amounts of LO and PH correlated well with interstitial cell hyperplasia 4-5 days after exposure and indicated that connective tissue protein synthesis is activated soon after cadmium exposure.
Descriptors (primary) lung tissue reaction; biochemistry of the lung; aerosols; cadmium and compounds
Descriptors (secondary) hydroxylases; enzyme disturbances; oxidases; animal experiments; cadmium chloride; connective tissue development
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Cadmium and compounds
Inorganic substances