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Document ID (ISN)38061
CIS number 82-1353
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1981
Convention or series no.
Author(s) Ellis K.J., Morgan W.D., Zanzi I., Yasumura S., Vartsky D., Cohn S.H.
Title Critical concentrations of cadmium in human renal cortex: dose-effect studies in cadmium smelter workers
Bibliographic information May 1981, Vol.7, No.5, 691-703p. 23 ref.
Abstract Cadmium (Cd) was measured in vivo (using a neutron activation technique) in the left kidney and liver of 82 industrially exposed workers and 10 control subjects. The range of Cd values for the industrial group was 0.9-57mg for the whole kidney and 0.8-120ppm for the liver, compared to 0.4-11.8mg and 0.6-7.9ppm for the controls. At <40ppm in the liver, the kidney Cd burden increased with increasing liver concentration. At >40ppm, the kidney Cd content decreased as the liver concentration increased. This relation between Cd in the kidney and the liver for all subjects showed a critical level (Cd burden at which adverse effects occurred in the kidney) of 31mg Cd in the kidney. Estimates of the critical level by β2-microglobulin and urinary protein measurements yielded values of 31-42mg Cd for the whole kidney (300-400µg/g for the renal cortex).
Descriptors (primary) renal diseases; non-ferrous metal industries; cadmium; nephrotoxic effects
Descriptors (secondary) proteinuria; exposure evaluation; comparative study; urine monitoring; scintillation scanning; dose-response relationship
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Diseases of the kidney and the urinary system
Smelting and refining operations
Cadmium and compounds
Inorganic substances