Document ID (ISN) | 37886 |
CIS number |
82-1095 |
ISSN - Serial title |
0002-8894 - American Industrial Hygiene Association Journal |
Year |
1981 |
Convention or series no. |
|
Author(s) |
Beck J.F., Bradbury C.M., Connors A.J., Donini J.C. |
Title |
Nitrite as an antidote for acute hydrogen sulfide intoxication ? |
Bibliographic information |
Nov. 1981, Vol.42, No.11, p.805-809. Illus. 24 ref. |
Abstract |
In the detoxicification of hydrogen sulfide by a haeme-catalysed oxidation, interlocking oxygen (O2) absorption and sulfide depletion data indicate that both oxyhaemoglobin and methaemoglobin are effective catalytic agents. The life time of excess sulfide in the presence of O2 and either of these catalysts is only minutes. The formation of methaemoglobin following nitrite administration occurs preferentially in O2-poor conditions and, in an atmospheric or O2-rich environment, which favours sulfide depletion, the nitrite retards sulfide oxidation. Nitrite as an antidote is only effective within the first few minutes after exposure, and at this time resuscitation and ventilation of the victim produce conditions in which nitrite slows sulfide removal. |
Descriptors (primary) |
metabolic detoxication; nitrites; antidote treatment; toxicology; hydrogen sulfide |
Descriptors (secondary) |
acute poisoning; haemoglobin monitoring; catalytic oxidation |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology
|
Broad subject area(s) |
|
Browse category(ies) |
Inorganic sulfur compounds Inorganic substances
|