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CISDOC database

Document ID (ISN)37807
CIS number 82-1130
ISSN - Serial title 0140-6736 - Lancet
Year 1982
Convention or series no.
Author(s) Misra U.K., Nag D., Misra N.K., Krishna Murti C.R.
Title Macular degeneration associated with chronic pesticide exposure
Bibliographic information 30 Jan. 1982, Vol.1, No.8266, p.288. 6 ref.
Abstract 64 workers in a malaria control unit sprayed Baytex, Temephos (both organic thiophosphates) and Paris green (copper acetoarsenite) in oil for 5-6h per day without use of protective clothing, face masks or gloves. On examination 14 members of the group, aged 24-42 years with exposure in the range 1-8 years, had macular involvement. Symptoms included visual impairment, dislike of bright light, night blindness, black dots in front of the eyes and blurring of vision. Visual acuity was reduced in 9 subjects. Macular degeneration was characterised by areas of perifoveal depigmentation, dull foveal reflex, and bilaterial lesions. Clinical evaluation did not reveal any known cause for this high-frequency of macular degeneration, and the macular toxicity of the pesticides is suspected as the cause.
Descriptors (primary) arsenites; organic thiophosphates; retinal damage; corneal damage; pesticides
Descriptors (secondary) Paris Green; insecticides; crop protection; temephos; ophthalmotoxic effects; fenthion; developing countries; long-term exposure
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Diseases of the eye and vision damage
Agricultural chemicals
Esters and salts
Arsenic and compounds
Inorganic substances