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CISDOC database

Document ID (ISN)37450
CIS number 82-748
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1981
Convention or series no.
Author(s) Innocenti A., Franzinelli A., Sartorelli E.
Title Longitudinal study of workers suffering from polyurethane asthma
Original title Studio longitudinale in lavoratori affetti da asma da resine poliuretaniche [in Italian]
Bibliographic information May-June 1981, Vol.72, No.3, p.231-237. 43 ref.
Abstract In 37 polyurethane production workers with isocyanate asthma, examinations carried out 40 months after exposure had ceased showed that asthmatic symptoms had disappeared in 32 workers but that chronic bronchitis had developed in 6. The progressive impairment of ventilatory function was evaluated by measuring the decrease in forced vital capacity (FVC) and FEV1 after exposure had ceased. Mean annual decreases of 86.3 and 67.7ml, respectively, were observed. Tolylene diisocyanate induces chronic and irreversible lung damage even after exposure is discontinued and impairment of FVC is greater than that of FEV1.
Descriptors (primary) chronic bronchitis; isocyanates; respiratory impairment; plastics converting industry; asthma
Descriptors (secondary) polyurethanes; 2,6-tolylene diisocyanate; 2,4-tolylene diisocyanate; delayed effects; one-second forced expiratory volume; long-term study; maximal expiratory flow
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Cyano compounds