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Document ID (ISN)37445
CIS number 82-744
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1981
Convention or series no.
Author(s) Suciu I., Prodan L., Lazar V., Ilea E., Cicīrla A., Olinici L., Paduraru A., Zagreanu O., Lengyel P., Györffi L., Andru D.
Title Research on copper poisoning
Bibliographic information May-June 1981, Vol.72, No.3, p.190-197. 8 ref.
Abstract Yearly examinations were performed on 75-100 workers involved in grinding and sieving copper (Cu) dust, over a 4 year period. 4 stages of Cu poisoning were identified. In the first stage the serum Cu was > 80µg%, with increased alpha-2-globulins, red bloodcells and haemoglobin. There was also hepatomegaly, gingivitis and a yellowish green line on the gums. In the second stage nervous disorders, gastro-intestinal disorders with hepatomegaly, anorexia, nausea, vomiting, and congestion of the face were also observed. Chronic irritative bronchitis, with yellowish green sputum, sexual impotency and non-secretory adenoma of the hypophysis with modifications of the sella turcica also occurred. The third stage was characterised by the appearance of organic lesions, sensitive polyneuritis and chronic hepatitis. In the 4th stage the organic symptoms were decompensated. Cu elimination from the body was obtained with D-penicillamine and chelation treatment.
Descriptors (primary) copper; chronic poisoning; respirable dust
Descriptors (secondary) hepatic damage; respiratory impairment; dyspnoea; functional digestive disorders; neurasthenia; bronchitis; pituitary disorders; gingivitis; hepatitis; polyneuritis; impotence; neurological effects; electrical industry; chelation therapy; symptoms
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Copper and compounds
Inorganic substances