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CISDOC database

Document ID (ISN)37266
CIS number 82-464
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1981
Convention or series no.
Author(s) Kirwin C.J., LeBlanc J.V., Thomas W.C., Haworth S.R., Kirby P.E., Thilagar A., Bowman J.T., Brusick D.J.
Title Evaluation of the genetic activity of industrially produced carbon black
Bibliographic information June 1981, Vol.7, No.6, p.973-989. 39 ref.
Abstract The genetic activity of a commercially produced oil furnace black, containing 294ppm polynuclear aromatic hydrocarbons, was evaluated using the Ames Salmonella typhimurium reverse mutation test, sister chromatid exchange test in CHO cells, mouse lymphoma test, cell transformation assay, and assay for genetic effects in Drosophila melanogaster. Limited cellular toxicity was exhibited but no significant genetic activity was found.
Descriptors (primary) carbon black; cytotoxic effects; genetic effects
Descriptors (secondary) mutagenic effects; toxic effects; chromosome changes; polycyclic hydrocarbons; aromatic hydrocarbons
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects