ILO Home
Go to the home page
Site map | Contact us Français | Español

CISDOC database

Document ID (ISN)36846
CIS number 82-219
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1981
Convention or series no.
Author(s) Nelson J., MacKinnon E.A., Mower H.F., Wong L.
Title Mutagenicity of N-nitroso derivatives of carbofuran and its toxic metabolites
Bibliographic information Mar.-Apr. 1981, Vol.7, No.3-4, p.519-531. Illus. 21 ref.
Abstract In the Ames assay method the nitroso derivatives of carbofuran (CF), 3-hydroxycarbofuran (HCF) and 3-ketocarbofuran (KCF) all gave a mutation ratio of 45 at 5µg per plate Salmonella typhimurium strain TA 100. All three nitroso derivatives also produced chromosome aberrations in Chinese hamster ovary cells. Nitroso derivatives of CF and HCF induced large numbers of sister chromatid exchanges in the same cells.
Descriptors (primary) mutagenic effects; insecticides; carbofuran; nitroso compounds
Descriptors (secondary) 3-hydroxycarbofuran; chromosome changes; nematocides; 3-ketocarbofuran
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Agricultural chemicals
Genetic factors in reaction to exposures