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Document ID (ISN)36747
CIS number 81-2015
ISSN - Serial title 0004-1254 - Arhiv za higijenu rada i toksikologiju
Year 1981
Convention or series no.
Author(s) Horvat Dj., Račić J., Rozgaj R.
Title Frequency of sister chromatid exchanges in V79 cells of Chinese hamsters exposed to heavy metals
Original title Učestalost izmjena kromatida sestara u V79 stanica kineskog hrčka nakon izloženosti teškim metalima [in Serbocroatian]
Bibliographic information 1981, Vol.32, No.2, p.147-156. Illus. 26 ref.
Abstract The sister chromatid exchange (SCE) method was used to investigate the mutagenic effect of heavy metals (Pb++, MN++, Ni++, Cd++). In vitro experiments with Chinese hamster V79 cells showed that Pb and Ni did not cause any significant change in SCE values, whereas exposure to Mn and Cd increased the number of changes; in particular, Cd had a marked mutagenic effect, doubling the number of exchanges after 2-h cell incubation.
Descriptors (primary) manganese; nickel; cadmium; chromosome changes; cytotoxic effects; lead
Descriptors (secondary) in vitro experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Nickel and compounds
Cadmium and compounds
Lead and compounds
Inorganic substances