Document ID (ISN) | 36747 |
CIS number |
81-2015 |
ISSN - Serial title |
0004-1254 - Arhiv za higijenu rada i toksikologiju |
Year |
1981 |
Convention or series no. |
|
Author(s) |
Horvat Dj., Račić J., Rozgaj R. |
Title |
Frequency of sister chromatid exchanges in V79 cells of Chinese hamsters exposed to heavy metals |
Original title |
Učestalost izmjena kromatida sestara u V79 stanica kineskog hrčka nakon izloženosti teškim metalima [in Serbocroatian] |
Bibliographic information |
1981, Vol.32, No.2, p.147-156. Illus. 26 ref. |
Abstract |
The sister chromatid exchange (SCE) method was used to investigate the mutagenic effect of heavy metals (Pb++, MN++, Ni++, Cd++). In vitro experiments with Chinese hamster V79 cells showed that Pb and Ni did not cause any significant change in SCE values, whereas exposure to Mn and Cd increased the number of changes; in particular, Cd had a marked mutagenic effect, doubling the number of exchanges after 2-h cell incubation. |
Descriptors (primary) |
manganese; nickel; cadmium; chromosome changes; cytotoxic effects; lead |
Descriptors (secondary) |
in vitro experiments |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology
|
Broad subject area(s) |
|
Browse category(ies) |
Antifertility and prenatal effects Genetic factors in reaction to exposures Nickel and compounds Cadmium and compounds Lead and compounds Inorganic substances
|