ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)36607
CIS number 81-1996
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1980
Convention or series no.
Author(s) Forni A., SciamŔ A., Bertazzi P.A., Alessio L.
Title Chromosome and biochemical studies in women occupationally exposed to lead
Bibliographic information May-June 1980, Vol.35, No.3, p.139-145. 13 ref.
Abstract Blood lead levels and erythrocyte protoporphyrin and δ-aminolevulinic acid dehydratase activity of red blood cells were determined for 18 healthy females occupationally exposed to lead in the manufacture of electrical storage batteries and 12 female controls. Cytogenetic studies were performed on lymphocytes cultured for 2 and 3 days with phytohaemagglutinin. Significantly increased rates of metaphases with chromatid and chromosome aberrations, excluding gaps, were observed in the exposed vs. the control group at both culture times. The yield of abnormal metaphases was higher in the 3-day than in the 2-day cultures, in both exposed and control groups, but the difference was only moderately significant for controls and highly significant for those exposed. These results are consistent with those found for males.
Descriptors (primary) lead; biochemical effects; women; battery and dry cell manufacture; chromosome changes
Descriptors (secondary) comparative study; analysis of chromosome aberrations
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Manufacturing of electrical appliances and equipment
Lead and compounds
Inorganic substances