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CISDOC database
| Document ID (ISN) | 36576 |
| CIS number |
81-1986 |
| ISSN - Serial title |
0009-9309 - Clinical Toxicology |
| Year |
1981 |
| Convention or series no. |
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| Author(s) |
Reuber M.D. |
| Title |
Carcinogenicity of dichlorvos |
| Bibliographic information |
1981, Vol.18, No.1, p.47-84. 21 ref. |
| Abstract |
Chronic and sub-chronic studies on rats, mice, dogs and swine, carried out at the National Cancer Institute (USA), and in the Tunstall, Kettering, and Shell Chemical Co. laboratories are summarised. The animals studied were exposed to dichlorvos (DCV) for periods of 5 weeks to 2 years and DCV was carcinogenic for rats and mice and toxic for dogs and swine. Specific findings included: an increase in benign and malignant neoplasms at all sites in male rats; increases in neoplasms of the endocrine organs in male and female rats and of the adrenal gland and pituitary in female rats, and the thyroid and mammary gland in male rats; fatty change and cholestasis of the liver, chronic interstitial nephritis, periarteritis, and atrophy of the testes in rats; carcinogenic effects on the liver, oesophagus, and forestomach of male mice, and the bone of female mice; atrophy of the testes in male mice; dose-related hepatic changes in dogs and swine; chronic renal disease in dogs; dose-related reductions in cholinesterase activity in rats, dogs and swine. |
| Descriptors (primary) |
carcinogens; pesticides; dichlorvos |
| Descriptors (secondary) |
mutagenic effects; neoplasms; animal experiments; toxic effects |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
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| Browse category(ies) |
Agricultural chemicals
Genetic factors in reaction to exposures
Esters and salts
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