|Document ID (ISN)||36562|
|Convention or series no.
||Arbete och hälsa 1981:6
||Ehrenberg L., Hällström T., Osterman-Golkar S.
||Criteria document for threshold limit values: Ethylene oxide
||Kriteriedokument för gränsvärden - Etylenoxid [in Swedish]|
||Arbetarskyddsverket, 171 84 Solna, Sweden, 1981. 33p. 73 ref.
||This literature survey presents evidence for the mutagenic and carcinogenic effects of ethylene oxide (EO) in all groups of organisms from bacteria to mammals. Experimental and epidemiologic data show that a linear dose-dependent relationship exists for induction of mutation and tumours by EO and that there is no no-effect threshold. A reaction-kinetic and pharmaco-kinetic model was used to estimate that 6 tumours/year would result from 40h/week exposure of 1,000 persons at 1ppm. Epidemiologic studies of two occupationally exposed populations confirmed the order of magnitude of this estimate.
||mutagenic effects; carcinogenic effects; ethylene oxide
||literature survey; probability analysis; threshold limit values; mathematical models; epidemiologic study; animal experiments; dose-response relationship; Sweden
||E - Books, reports, proceedings
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures