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Document ID (ISN)36562
CIS number 81-1943
ISBN(s) 91-7464-096-8
Year 1981
Convention or series no. Arbete och hälsa 1981:6
Author(s) Ehrenberg L., Hällström T., Osterman-Golkar S.
Title Criteria document for threshold limit values: Ethylene oxide
Original title Kriteriedokument för gränsvärden - Etylenoxid [in Swedish]
Bibliographic information Arbetarskyddsverket, 171 84 Solna, Sweden, 1981. 33p. 73 ref.
Abstract This literature survey presents evidence for the mutagenic and carcinogenic effects of ethylene oxide (EO) in all groups of organisms from bacteria to mammals. Experimental and epidemiologic data show that a linear dose-dependent relationship exists for induction of mutation and tumours by EO and that there is no no-effect threshold. A reaction-kinetic and pharmaco-kinetic model was used to estimate that 6 tumours/year would result from 40h/week exposure of 1,000 persons at 1ppm. Epidemiologic studies of two occupationally exposed populations confirmed the order of magnitude of this estimate.
Descriptors (primary) mutagenic effects; carcinogenic effects; ethylene oxide
Descriptors (secondary) literature survey; probability analysis; threshold limit values; mathematical models; epidemiologic study; animal experiments; dose-response relationship; Sweden
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Ethers
Ethylene oxide
Genetic factors in reaction to exposures