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Document ID (ISN)36461
CIS number 81-1678
ISSN - Serial title 0019-8366 - Industrial Health
Year 1981
Convention or series no.
Author(s) Mithal R.K.
Title Histopathological studies with reference to chronic cadmium exposure in adrenal and spleen of common Indian ground squirrel
Bibliographic information 1981, Vol.19, No.1, p.9-14. Illus. 8 ref.
Abstract Ground squirrels were injected intraperitoneally with a daily dose of cadmium acetate, at 1.0mg Cd/kg body weight, for 4, 5, 6 and 7 weeks, and the adrenals and spleen of exposed animals were compared with those of controls. The adrenals showed dilatation of sinusoids, fatty change in the cells of the cortex, hyaline-like mass in the medulla, haemorrhage adjacent to the medulla, circumscribed haemorrhage in the cortex, and congested blood vessels. The spleen showed congestion in blood vessels, thickening of vessel walls, and congestion and dilatation of sinusoids. The body weight gain of Cd-exposed animals was significantly lower than that of the controls, and the increase in spleen weight was significantly higher.
Descriptors (primary) splenic diseases; cadmium; histopathology; adrenal gland disorders
Descriptors (secondary) spleen; cadmium acetate; body weight; long-term exposure; chronic toxicity; animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Blood diseases
Cadmium and compounds
Inorganic substances
Endocrine diseases