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Document ID (ISN)35738
CIS number 81-1023
Year 1980
Convention or series no.
Author(s) Balogh T., Ungváry G., Tátrai E., Hudák A., Lőrincz M., Barcza G.
Title Experimental model for use in the study of malformations caused by interaction of chemicals and therapeutic drugs.
Bibliographic information Research Institute for Labour Safety, National Institute of Occupational Health, Budapest, Hungary, 22-25 Sep. 1980, p.133-144. 24 ref.
Abstract Pregnant rats were exposed to toluene at 3,600mg/m3 atmospheric concentration from day 10 to 13 of gestation. Acetylsalicyclic acid was administered at a dose of 500mg/kg on the 12th day of gestation. An increase in maternal toxicity and in mortality among mothers, a decrease in food consumption and weight gain and an increase in the liver-to-body weight ratio resulted in the treated group. Foetal toxicity increased. Foetal mortality, the incidence of sternum anomalies and extra ribs were higher, and the weight of foetuses decreased. Toluene alone, applied throughout organogenesis at the same concentration, was not teratogenic. The embryotoxic effects observed in this study resulted from overlapping metabolic pathways for the two chemicals: conjugation with glycine of benzoic acid, derived from toluene, to form hippuric acid, takes up the glycine which is also needed for conjugation of acetylsalicyclic acid. This results in enhanced levels of free acid in the maternal blood.
Descriptors (primary) embryotoxic effects; toluene; expectant mothers; teratogenic effects; synergism; analgesics
Descriptors (secondary) metabolic process; animal experiments; acetylsalicylic acid
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Aromatic hydrocarbons
Genetic factors in reaction to exposures