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CISDOC database

Document ID (ISN)35469
CIS number 81-770
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1980
Convention or series no.
Author(s) Sato A., Nakajima T., Koyama Y.
Title Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats.
Bibliographic information Nov. 1980, Vol.37, No.4, p.382-386. 23 ref.
Abstract The activities of liver drug-metabolising enzymes for 16 aromatic or chlorinated hydrocarbons were measured in rats after daily intake of ethanol (30% of total energy intake) for 3 weeks. Ethanol only slightly increased the microsomal cytochrome P-450 content, but increased in vitro metabolism of most hydrocarbons 3-6 fold. A major part of this enhanced activity disappeared after withdrawal of ethanol, suggesting that recent intake of ethanol plays an important part in accelerating the metabolism of hydrocarbons. The enzyme activity enhanced by ethanol was related to changes occurring not in the soluble but in the microsomal fractions. A metabolism study with toluene showed its in vivo metabolism to be increased by chronic ethanol consumption in rats.
Descriptors (primary) metabolic process; aromatic hydrocarbons; synergism; chlorinated hydrocarbons; ethanol
Descriptors (secondary) toluene; alcoholism; in vitro experiments; animal experiments; enzyme activity
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Alcohol and drug abuse
Aromatic hydrocarbons
Halogenated hydrocarbons