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Document ID (ISN)35333
CIS number 81-754
ISSN - Serial title 0009-0573 - Československß hygiena
Year 1979
Convention or series no.
Author(s) Koudela K., Spazier K.
Title Effects of dimethylformamide on human peripheral lymphocytes
Original title Vliv dimetylformamidu na lidskÚ perifernÝ lymfocyty [in Czech]
Bibliographic information Nov. 1979, Vol.24, No.9, p.432-436. Illus. 10 ref.
Abstract Cytogenetic analysis of peripheral lymphocytes from the blood of 3 healthy volunteers indicated that dimethylformamide induces mutations in somatic cells. Dimethylformamide had a mutagenic activity 3-4 times lower than that of thio-TEPA, a mutagen used in cancer therapy. The chromosome aberrations caused by dimethylformamide are consistent with the type of lesions caused by chemical mutagens.
Descriptors (primary) mutagenic effects; chromosome changes; toxic substances; dimethylformamide
Descriptors (secondary) human experiments; cytogenetic studies; in vitro experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures