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CISDOC database

Document ID (ISN)34927
CIS number 81-171
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1980
Convention or series no.
Author(s) Andersen M., Binderup M.L., Kiel P., Larsen H., Maxild J.
Title Mutagenic action of isocyanates used in the production of polyurethanes.
Bibliographic information Sep. 1980, Vol.6, No.3, p.221-226. Illus. 20 ref.
Abstract Toluene diisocyanate (TDI), 4-4'-methylenediphenyl isocyanate (MDI), 1,6-hexane diisocyanate (HDI), phenyl isocyanate, and 1-naphthyl isocyanate, were tested for mutagenicity in Salmonella. TDI, 1-naphthyl isocyanate, and MDI were mutagenic after metabolic activation. The effect is ascribed to the amine analogues formed during hydrolysis. Isocyanates are thus potentially mutagenic and carcinogenic to man.
Descriptors (primary) mutagens; plastics industry; isocyanates; polyurethanes
Descriptors (secondary) diphenylmethane diisocyanate; metabolic process; 2,4-tolylene diisocyanate; hexamethylene diisocyanate; 1-naphthyl isocyanate; phenyl isocyanate
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Chemical industry
Isocyanates
Cyano compounds
Plastics industry