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CISDOC database

Document ID (ISN)34387
CIS number 80-1692
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1980
Convention or series no.
Author(s) Watanabe T., Endo A., Kato Y., Shima S., Ikeda M.
Title Cytogenetics and cytokinetics of cultured lymphocytes from benzene-exposed workers.
Bibliographic information 1980, Vol.46, No.1, p.31-41. 26 ref.
Abstract Chromosome aberrations, sister-chromatid exchange frequencies and cell-cycle kinetics of cultured lymphocytes from benzene-exposed workers (40ppm for < 20 years) were examined. While no increase in the number of structural and numerical chromosome aberrations nor any changes in cell-cycle kinetics were observed, a slight decrease in the frequency of sister-chromatid exchanges was detected. This decrease may be a manifestation of the subtler effect of benzene on the DNA replication mechanism. Possible dose-effect relation in benzene-induced chromosome aberrations is discussed.
Descriptors (primary) benzene; pottery industry; chromosome changes
Descriptors (secondary) paint thinners; cytogenetic studies; dose-response relationship
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Aromatic hydrocarbons
Glass, pottery and related materials
Genetic factors in reaction to exposures