| Document ID (ISN) | 33221 |
| CIS number |
80-762 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
1979 |
| Convention or series no. |
|
| Author(s) |
Ishihara N., Ikeda M. |
| Title |
Effects of solvents and solutes on the percutaneous absorption of m-dinitrobenzene. |
| Bibliographic information |
Sep. 1979, Vol.44, No.2, p.91-98. 19 ref. |
| Abstract |
Following a case of intoxication in electronic components production, a survey of the exposed workers and skin application experiments with guinea pigs were carried out using m-dinitrobenzene dissolved in a mixture of ethylene and diethylene glycol and ammonium sebacate. With a concentration of ethylene glycol over 77,5%, the solution produced methaemoglobinaemia in guinea pigs. Replacement of ammonium sebacate with diammonium salt of adipic acid or malonic acid also made the formulation capable of methaemoglobin formation. All of the formulations did not provoke skin irritation in guinea pigs. The most plausible explanation of the effects observed is water impregnation of the stratum corneum by ethylene glycol which is more hygroscopic. |
| Descriptors (primary) |
dinitrobenzene; skin absorption; electronics industry; haematotoxic effects; organic solvents |
| Descriptors (secondary) |
adipic acid; diethylene glycol; m-dinitrobenzene; methaemoglobinaemia; malonic acid; animal experiments; ethylene glycol |
| Document type |
- |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Manufacturing of electrical appliances and equipment
Aliphatic nitro compounds
Electronics industry
|
