ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)33047
CIS number 80-460
ISSN - Serial title 0140-6736 - Lancet
Year 1979
Convention or series no.
Author(s) Mitelman F., Nilsson P.G., Brandt L., Alimena G., Montuoro A., Dallapiccola B.
Title Chromosomes, leukaemia, and occupational exposure to leukaemogenic agents.
Bibliographic information 1 Dec. 1979, Vol.II, No.8153, p.1195-1196. 5 ref.
Abstract The study abstracted under CIS 80-459 was extended to a total of 156 patients with acute non-lymphocytic leukaemia (ANLL). Clonal chromosomal aberrations were significantly more common in exposed than non-exposed patients: 76% of exposed, 32% of non-exposed. 9 of the 12 patients with normal chromosomes were exposed to petroleum products or their combustion residues; 32 of 34 patients exposed to chemical solvents and insecticides had abnormal chromosomes. Possible causes of conflicting results with other studies are discussed. Prospective studies are in progress.
Descriptors (primary) leukaemogenic effects; chromosome changes; harmful substances; leukaemia
Descriptors (secondary) Sweden; petroleum products; Italy; ongoing research; organic solvents; pyrolysis products; survey; insecticides
Document type -
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Leukaemia
Genetic factors in reaction to exposures
Antifertility and prenatal effects