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CISDOC database

Document ID (ISN)32926
CIS number 80-371
ISSN - Serial title 0036-8075 - Science
Year 1979
Convention or series no.
Author(s) Liebeskind D., Bases R., Mendez F., Elequin F., Koenigsberg M.
Title Sister chromatid exchanges in human lymphocytes after exposure to diagnostic ultrasound.
Bibliographic information 21 Sep. 1979, Vol.205, p.1273-1275. 19 ref.
Abstract Report on the effects of ultrasound on the incidence of sister chromatid exchanges (SCE), a sensitive direct indicator of chromosome damage. Exposure to diagnostic levels of ultrasound increased the frequency of SCE in freshly isolated human lymphocytes as well as in a continuously growing human lymphoblast line. The in-vitro methods of blood treatment, staining and exposure to ultrasound (30min, 700 pulses per second) are described. Temporal average intensity is estimated to be as high as 5.0mW/cm2. The mechanism of SCE and the relationship between SCE frequency and mutagenic potential are discussed. The results confirm previous findings indicating that ultrasound can affect the DNA of animal cells, and suggest that ultrasound may not be entirely innocuous.
Descriptors (primary) ultrasound; extra-auditory effects; chromosome changes
Descriptors (secondary) mutagenic effects; comparative study; in vitro experiments
Document type -
Subject(s) Noise, hearing and vibration
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures