ILO Home
Go to the home page
Site map | Contact us Français | Espańol

CISDOC database

Document ID (ISN)32482
CIS number 79-1948
ISSN - Serial title 0032-6291 - Pracovní lékařství
Year 1979
Convention or series no.
Author(s) Znojemská S., Janečková V., Pekárek J.
Title Experimental evaluation of sensitising properties of new chemicals
Original title Experimentální hodnocení senzibilizačních vlastností nových chemických látek [in Czech]
Bibliographic information July 1979, Vol.31, No.6-7, p.218-222. 17 ref.
Abstract Comparative studies of various methods in 1,200 guinea pigs are reported: maximisation test of Magnusson and Kligman, Maguire's test; Alexeyeva's test, single injection into paw, and repeated sacrification conducted with 5 known and 5 new substances. The allergic nature of the skin reactions was verified by macrophage migration inhibition tests. The best results were obtained with Magnusson's and Alexeyeva's methods. For new substances, tests in 20-25 animals are recommended, using 2 types of tests at least one of which would be a patch test.
Descriptors (primary) allergens; chemical products; sensitization; skin tests; hazard evaluation
Descriptors (secondary) skin allergies; comparative study; description of technique; animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Risk evaluation