| Document ID (ISN) | 32482 |
| CIS number |
79-1948 |
| ISSN - Serial title |
0032-6291 - Pracovní lékařství |
| Year |
1979 |
| Convention or series no. |
|
| Author(s) |
Znojemská S., Janečková V., Pekárek J. |
| Title |
Experimental evaluation of sensitising properties of new chemicals |
| Original title |
Experimentální hodnocení senzibilizačních vlastností nových chemických látek [in Czech] |
| Bibliographic information |
July 1979, Vol.31, No.6-7, p.218-222. 17 ref. |
| Abstract |
Comparative studies of various methods in 1,200 guinea pigs are reported: maximisation test of Magnusson and Kligman, Maguire's test; Alexeyeva's test, single injection into paw, and repeated sacrification conducted with 5 known and 5 new substances. The allergic nature of the skin reactions was verified by macrophage migration inhibition tests. The best results were obtained with Magnusson's and Alexeyeva's methods. For new substances, tests in 20-25 animals are recommended, using 2 types of tests at least one of which would be a patch test. |
| Descriptors (primary) |
allergens; chemical products; sensitization; skin tests; hazard evaluation |
| Descriptors (secondary) |
skin allergies; comparative study; description of technique; animal experiments |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Risk evaluation
|
