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Document ID (ISN)31871
CIS number 79-1369
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1979
Convention or series no.
Author(s) Milkov L.E., Aldyreva M.V.
Title Establishment, on the basis of epidemiologic studies, of TLVs of chemical substances (on the example of chronic effects of dibutyl phthalate)
Original title O kliniko-gigieničeskom obosnovanii predel'no dopustimyh koncentracij himičeskih veščestv (na primere hroničeskogo vozdejstvija dibutilftalata) [in Russian]
Bibliographic information Feb. 1979, No.2, p.1-5. 9 ref.
Abstract For the establishment of reliable TLVs the authors recommend epidemiologic studies followed by statistical evaluation of the data obtained on the health damage sustained by exposed workers. They present the results of dynamic health status case studies in 651 workers exposed to dibutyl phthalate in producing PVC-base films. An early sign of sensorial disturbances is the lowering of the pain sensitivity threshold; the frequency of this phenomenon depends on the number of years of employment and the concentrations of dibutyl phthalate. A regressive linear equation is presented, enabling a TLV to be established with sufficient empirical precision.
Descriptors (primary) threshold limit values; USSR; determination of exposure limits; harmful substances; epidemiologic study; dibutyl phthalate
Descriptors (secondary) pain sensitivity threshold; health impairment; plastics industry; dose-response relationship; statistical evaluation; long-term exposure
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Occupational exposure limits
Esters and salts