| Document ID (ISN) | 31762 |
| CIS number |
79-1405 |
| ISSN - Serial title |
0040-6376 - Thorax |
| Year |
1979 |
| Convention or series no. |
|
| Author(s) |
Levin P.J., Klaff L.J., Rose A.G., Ferguson A.D. |
| Title |
Pulmonary effects of contact exposure to paraquat: A clinical and experimental study. |
| Bibliographic information |
Apr. 1979, Vol.34, No.2, p.150-160. Illus. 23 ref. |
| Abstract |
The clinical and pathological features of a patient who died from the effects of percutaneous absorption of paraquat, and of 9 less heavily exposed workers, are described. In the fatal case, the patient had balanced the spray reservoir on his shoulder, onto which it had leaked causing a burn (skin ulcer). In animal experiments, low concentrations of paraquat were applied to the skin of rats over 9 weeks. Pulmonary arterial lesions contrasting with the familiar pathological findings of acute high-dose ingestion occurred. Routine use of paraquat may cause severe pulmonary vascular disease. |
| Descriptors (primary) |
herbicides; dermal toxicity; vascular diseases; paraquat |
| Descriptors (secondary) |
lung; case study; paraquat chloride; fatalities; crop protection; chemical burns; animal experiments; skin absorption |
| Document type |
- |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Cardiovascular diseases
Heterocyclic compounds
|
