Document ID (ISN) | 31661 |
CIS number |
79-1070 |
ISSN - Serial title |
1775-8785 - Archives des maladies professionnelles |
Year |
1978 |
Convention or series no. |
|
Author(s) |
Boudène C., Belegaud J., Jouany J.M., Truhaut R. |
Title |
"In vivo" carbon monoxide production following exposure to dichloromethane |
Original title |
Sur la production "in vivo" d'oxyde de carbone après exposition au dichlorométhane. [in French] |
Bibliographic information |
Dec. 1978, Vol.39, No.12, p.657-669. Illus. 26 ref. |
Abstract |
Report on 3 series of experiments involving dichloromethane (CH2Cl2) inhalation by rabbits. In the first series the animals were exposed for 1h to increasing (500, 3,500, 5,000 and 7,000ppm) CH2Cl2 concentrations: all these concentrations were followed by abnormally high blood CO levels; the rate of increase confirmed the hypothesis of formation of CO being due to metabolic process. The second series (exposure to decreasing CH2Cl2 concentrations - from 200 to 80ppm, and exposure to 50ppm CO) suggested that blood CO levels approximating to those resulting from exposure the maximum allowable CO concentration (50ppm) are produced by exposure to a 100ppm CH2Cl2 concentration. This would be an argument in favour of reviewing and reducing the present TLV for this substance (200ppm). The third series invalidates the hypothesis of CH2Cl2 interfering with the affinity of haemoglobin with CO. |
Descriptors (primary) |
dichloromethane; carboxyhaemoglobin level; toxicology; carbon monoxide |
Descriptors (secondary) |
threshold limit values; inhalation toxicity; animal experiments; metabolic process |
Document type |
- |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
|
Browse category(ies) |
Blood diseases Carbon monoxide Halogenated hydrocarbons Inorganic substances
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