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Document ID (ISN)31661
CIS number 79-1070
ISSN - Serial title 1775-8785 - Archives des maladies professionnelles
Year 1978
Convention or series no.
Author(s) Boudène C., Belegaud J., Jouany J.M., Truhaut R.
Title "In vivo" carbon monoxide production following exposure to dichloromethane
Original title Sur la production "in vivo" d'oxyde de carbone après exposition au dichlorométhane. [in French]
Bibliographic information Dec. 1978, Vol.39, No.12, p.657-669. Illus. 26 ref.
Abstract Report on 3 series of experiments involving dichloromethane (CH2Cl2) inhalation by rabbits. In the first series the animals were exposed for 1h to increasing (500, 3,500, 5,000 and 7,000ppm) CH2Cl2 concentrations: all these concentrations were followed by abnormally high blood CO levels; the rate of increase confirmed the hypothesis of formation of CO being due to metabolic process. The second series (exposure to decreasing CH2Cl2 concentrations - from 200 to 80ppm, and exposure to 50ppm CO) suggested that blood CO levels approximating to those resulting from exposure the maximum allowable CO concentration (50ppm) are produced by exposure to a 100ppm CH2Cl2 concentration. This would be an argument in favour of reviewing and reducing the present TLV for this substance (200ppm). The third series invalidates the hypothesis of CH2Cl2 interfering with the affinity of haemoglobin with CO.
Descriptors (primary) dichloromethane; carboxyhaemoglobin level; toxicology; carbon monoxide
Descriptors (secondary) threshold limit values; inhalation toxicity; animal experiments; metabolic process
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Blood diseases
Carbon monoxide
Halogenated hydrocarbons
Inorganic substances