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CISDOC database

Document ID (ISN)31174
CIS number 79-675
ISSN - Serial title 0003-0805 - American Review of Respiratory Disease
Year 1978
Convention or series no.
Author(s) Snider D.E.
Title The realtionship between tuberculosis and silicosis.
Bibliographic information Sep. 1978, Vol.118, No.3, p.455-460. 54 ref.
Abstract This editorial article is a literature survey of the question, reporting information from a large number of countries and considering such aspects as the "walling-in" of tuberculosis foci by silicotic fibrosis (diagnosis being difficult as sufficient bacilli are not discharged into the sputum), the deleterious effect of silica on the ability of macrophages to inhibit the growth of bacilli, adjuvant effect of silica particles on antibody responses, increased susceptibility of persons with silicosis to other mycobacterial diseases, prevention of tuberculosis among population exposed to silica dust, contraindication of BCG vaccination, unpublished U.S. Public Health Service survey of 400 persons with anthracosilicosis, possibility that antituberculosis drugs do not readily penetrate into silicotic nodules, isoniazid preventive therapy, clinical signs, importance of chest roentgenography.
Descriptors (primary) silicosis; tuberculosis
Descriptors (secondary) literature survey; pharmacological prevention; mining industry; pneumoconiosis with tuberculosis; contraindication; isonicotinic acid hydrazide
Document type -
Subject(s) Dust, aerosols and related diseases
Broad subject area(s)
Browse category(ies) Bacterial and parasitic diseases
Pneumoconioses