| Document ID (ISN) | 30815 |
| CIS number |
79-484 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
1978 |
| Convention or series no. |
|
| Author(s) |
Ikeda M., Hirayama T., Watanabe T., Hara I. |
| Title |
GLC analysis of alkylphenols, alkylcatechols and phenylphenols in the urine of workers as a measure to prevent occupational leucoderma. |
| Bibliographic information |
1978, Vol.41, No.2, p.125-138. Illus. 19 ref. |
| Abstract |
Gas-liquid chromatographic systems are described for quantitative analysis of p-tert-butylphenol, p-tert-amylphenol, p-octylphenol, p- and o-phenylphenol, 3- and 4-methylcatechol, 3-isopropylcatechol, and 4-tert-butylcatechol. The systems were successfully applied for the exposure assessment of workers in the chemical industry producing p-tert-butylphenol, p-octylphenol and/or 4-tert-butylcatechol. Urine concentrations were higher in product packers, who had higher estimated exposure, than in plant operators and engineers. They were reduced by improved hygiene conditions in the workshops. The importance of biological monitoring is discussed in connection with possible skin penetration. A urinary p-tert-butylphenol concentration of 2µg/ml is tentatively proposed as the biological limit to prevent a leucodermogenic effect. |
| Descriptors (primary) |
leukoderma; phenols; gas-liquid chromatography; urine monitoring; pyrocatechol |
| Descriptors (secondary) |
p-tert-butylphenol; 4-methylpyrocatechol; skin absorption; p-octylphenol; p-tert-amylphenol; 2-phenylphenol; 3-isopropylpyrocatechol; 4-tert-butylpyrocatechol; 3-methylpyrocatechol; biological threshold limits; exposure tests; description of technique; 4-phenylphenol |
| Document type |
- |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Alcohols
Biological monitoring
Skin diseases
Phenols and phenolic compounds
|
