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CISDOC database

Document ID (ISN)30315
CIS number 78-1946
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1978
Convention or series no.
Author(s) Fleig I., Thiess A.M.
Title Mutagenicity of vinyl chloride.
Bibliographic information Aug. 1978, Vol.20, No.8, p.557-561. Illus. 15 ref.
Abstract Chromosome analysis was done on lymphocyte cultures from (1) 6 workers with estimated vinyl cloride (VC) exposure and 4 workers with monitored exposure, (2) 20 workers with unknown exposure, presenting symptoms of VC disease, and one worker with angiosarcoma due to VC exposure, and (3) on bone marrow cells of hamsters after inhalation of 2,500 or 5,000ppm or i.p. injection of 300 or 600mg/kg. The rate of chromosome aberrations showed no significant difference from controls in group (1), whereas it was significantly increased in workers with symptoms of VC disease and the exposed animals.
Descriptors (primary) mutagenic effects; chromosome changes; vinyl chloride
Descriptors (secondary) liver cancer; analysis of chromosome aberrations; animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Halogenated hydrocarbons
Genetic factors in reaction to exposures