Document ID (ISN) | 30315 |
CIS number |
78-1946 |
ISSN - Serial title |
0096-1736 - Journal of Occupational Medicine |
Year |
1978 |
Convention or series no. |
|
Author(s) |
Fleig I., Thiess A.M. |
Title |
Mutagenicity of vinyl chloride. |
Bibliographic information |
Aug. 1978, Vol.20, No.8, p.557-561. Illus. 15 ref. |
Abstract |
Chromosome analysis was done on lymphocyte cultures from (1) 6 workers with estimated vinyl cloride (VC) exposure and 4 workers with monitored exposure, (2) 20 workers with unknown exposure, presenting symptoms of VC disease, and one worker with angiosarcoma due to VC exposure, and (3) on bone marrow cells of hamsters after inhalation of 2,500 or 5,000ppm or i.p. injection of 300 or 600mg/kg. The rate of chromosome aberrations showed no significant difference from controls in group (1), whereas it was significantly increased in workers with symptoms of VC disease and the exposed animals. |
Descriptors (primary) |
mutagenic effects; chromosome changes; vinyl chloride |
Descriptors (secondary) |
liver cancer; analysis of chromosome aberrations; animal experiments |
Document type |
- |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
|
Browse category(ies) |
Antifertility and prenatal effects Halogenated hydrocarbons Genetic factors in reaction to exposures
|