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CISDOC database

Document ID (ISN)30127
CIS number 78-1685
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1978
Convention or series no.
Author(s) Hine C.H., Pasi A., Stephens B.G.
Title Fatalities following exposure to 2-nitropropane.
Bibliographic information May 1978, Vol.20, No.5, p.333-337. 7 ref.
Abstract After a review of animal studies and observations in humans, 4 fatal case histories with postmortem findings in workers painting or coating in confined spaces without adequate protection are reported. The characteristic lesion was destruction of hepatocytes, and liver failure was the primary cause of death. Survival was 6-10 days. Symptoms usually included nausea, vomiting, diarrhoea, headache, dyspnoea, ataxia, and chest and abdominal pain. The inadequacy of warning labels is pointed out.
Descriptors (primary) acute poisoning; nitropropane; painting; work in confined spaces
Descriptors (secondary) hepatotoxic effects; case study; 2-nitropropane; fatalities; hepatic insufficiency; warning notices; symptoms
Document type -
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Confined spaces
Aliphatic nitro compounds
Surface treatment