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CISDOC database

Document ID (ISN)29855
CIS number 78-1373
ISSN - Serial title 0323-9179 - Problemi na higienata
Year 1978
Convention or series no.
Author(s) Koleva M.
Title Changes in urinary excretion of γ-glutamyl transpeptidase, leucine aminopeptidase and alkaline phosphatase on combined exposure to ethylene glycol and high temperature
Original title Promeni v ekskrecijata na gama-glutamiltranspeptidazata, levcinaminopeptidazata i alkalnata fosfataza v urinata pri kombinirano dejstvie na etilenglikol i visoka temperatura [in Bulgarian]
Bibliographic information 1977, Vol.3, p.35-46. 26 ref.
Abstract Results of experiments with rats to determine these changes 2, 8, 15, 30 and 90 days after exposure, separately or simultaneously, to ethylene glycol (EG) (1/8 LD50) and 35░C ambient temperature. The effect of ambient heat alone caused an increase in enzyme excretion at the early stage of exposure, whereas exposure to EG alone caused a reduction in γ-glutamyl transpeptidase (GTR) and leucine-aminopeptidase, and an increase in alkaline phosphatase excretion. The temperature factor attenuated the toxic effect of EG on these enzymes towards the end of the observation period. Changes in GTR excretion are the earliest and most sensitive sign of tubular lesions.
Descriptors (primary) temperature-toxicity synergism; ethylene glycol; hot workplaces; urinary excretion; enzyme disturbances
Descriptors (secondary) transpeptidases; aminopeptidase; animal experiments; renal damage; alkaline phosphatases
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Blood diseases
Glycols
Alcohols
Heat and cold