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CISDOC database
| Document ID (ISN) | 29307 |
| CIS number |
78-1010 |
| Year |
1977 |
| Convention or series no. |
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| Author(s) |
Berlin M., Fredga K., Gullberg B., Holm S., Knutsson P., Reitalu J., Tunek A. |
| Title |
Biological data on, and chromosome changes due to benzene exposure |
| Original title |
Biologiskt index för och kromosomförändringar vid bensenexposition [in Swedish] |
| Bibliographic information |
Rapport nr 771018, Institutionerna för Hygien, Genetik och Statistik, Lunds Universitet, Fack, 221 01 Lund, Sweden, 1977. 29p. Illus. 18 ref. |
| Abstract |
The relation between benzene exposure and concentration in exhaled air was studied in volunteers exposed to 3-10ppm benzene for 1-5 days, 3-6h per day. The accumulation and elimination of benzene via the respiratory tract can be described by a 3-compartment model with biological half-times of 2.5, 28, and 90h. At the steady state, the second compartment contributes about 75% of the benzene concentration in exhaled air 16h after the last exposure. The remaining 25% derives mainly (about 15%) from the compartment with the longest retention time, and less than 10% from the compartments with short retention times. The concentration of benzene in exhaled air, collected during rest ventilation 16h after exposure to 10ppm during 8h, 5 days per week (medium heavy work conditions), is about 0.1ppm. An epidemiological survey showed that exposure of 5-10ppm gives rise to chromosome changes in lymphocytes; these changes are not observed at 1ppm. English summary. |
| Descriptors (primary) |
benzene; dose-response relationship; chromosome changes; genetic effects |
| Descriptors (secondary) |
Sweden; report; human experiments; epidemiologic study; excretion |
| Document type |
E - Books, reports, proceedings |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
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| Browse category(ies) |
Aromatic hydrocarbons
Genetic factors in reaction to exposures
Antifertility and prenatal effects
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