| Document ID (ISN) | 29249 |
| CIS number |
78-801 |
| ISSN - Serial title |
0028-4793 - New England Journal of Medicine |
| Year |
1978 |
| Convention or series no. |
|
| Author(s) |
Cohn W.J., Boylan J.J., Blanke R.V., Fariss M.W., Howell J.R., Guzelian P.S. |
| Title |
Treatment of chlordecone (Kepone) toxicity with cholestyramine - Results of a controlled clinical trial. |
| Bibliographic information |
2 Feb. 1978, Vol.298, No.5, p.243-248. 24 ref. |
| Abstract |
Cholestyramine is an anion-exchange resin that binds chlordecone. It was given for 5 months to 12 workers who had been exposed to chlordecone during manufacture, while 10 received a placebo. The toxicity and modes of elimination of chlordecone before and after therapy are reported. Cholestyramine significantly accelerated elimination of chlordecone from blood and fat. The treatment offers a practical means of detoxifying persons exposed to this and possibly other lipophilic toxins. |
| Descriptors (primary) |
kepone; pesticides; chemotherapy; chronic poisoning; cholestyramine |
| Descriptors (secondary) |
ion exchangers; dose-response relationship; faecal excretion |
| Document type |
- |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Halogenated hydrocarbons
Agricultural chemicals
|
