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CISDOC database

Document ID (ISN)28879
CIS number 78-434
Year 1977
Convention or series no.
Author(s) Zingmark P.A., Rappe C.
Title Formation of N-nitrosodiethanolamine from a grinding fluid under simulated gastric conditions
Original title Etude par simulation de la formation de N-nitrosodiÚthanolamine dans l'estomac Ó partir des fluides de meulage. [in French]
Bibliographic information Traduction INRS 21 B-77, Institut national de recherche et de sÚcuritÚ, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1977. 9p. Illus. 15 ref.
Abstract Translation of: Formation of N-nitrosodiethanolamine from a grinding fluid under simulated gastric conditions. Ambio, Stockholm, Sweden, 1976. Vol.5, No.2, p.80-81. Illus. 17 ref. (CIS 76-1371). Nitroso amines are carcinogenic and they can be formed by reaction of amines and nitrites which are used as additives in industrial oils. A grinding fluid containing triethanolamine, sodium nitrite, water and fluorescein dye was kept at 37░C for 1h in buffer solutions at different gastric pH values. At pH 2, 1ml of fluid gave 13mg nitrosodiethanolamine, determined by gas chromatography. This amount is about 1,000 times the amount found in certain foods. The results at pH 3 and 3.5 are inconclusive. Although the compound is a weaker carcinogen than diethylnitrosamine, workers must be protected against mists of oils containing amines and nitrites.
Descriptors (primary) carcinogens; nitrosodiethanolamine; metalworking industry; cutting fluids
Descriptors (secondary) nitrites; translation; grinding machines; triethanolamine
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Metalworking industry